Beilstein J. Nanotechnol.2016,7, 62–67, doi:10.3762/bjnano.7.7
counterions present in a buffer. X-ray reflectivity at and away from the Cu K absorption edge and atomic force microscopy studies reveal that confinement segregates the drug molecules preferentially in a top layer of the DNA film, and counterions enhance this segregation.
Keywords: confinement; metal–drug
–DNAcomposites; polyelectrolyte; X-ray scattering; Introduction
Condensed state behaviour of DNA, the best-known biopolymer, in a confined space is a matter of interest due to its relevance in living systems. Within cells DNA molecules remain in a confined space crowded by other molecules and ions
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Figure 1:
Structure of (a) piroxicam molecule and (b) Cu(II)–piroxicam complex.